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高攝取量腦靶向O-去甲基文拉法辛前體藥物的研究與開發(fā)

成果領(lǐng)域: 精準醫(yī)療

推廣方式:

成果歸屬企業(yè): 吉林大學生命科學學院顧景凱教授科研團隊

成果鑒定時間:

成果介紹

抗抑郁是中樞疾病治療領(lǐng)域最為關(guān)注的問題?；诳挂钟羲嶰-去甲基文拉法辛（ODV）腦攝取不足的缺陷，項目團隊對其進行了結(jié)構(gòu)設(shè)計與優(yōu)化，開發(fā)了ODV酚酯類前體藥物。該前體藥物口服吸收良好、入血后快速透過血腦屏障，在腦組織代謝轉(zhuǎn)化為母體藥物ODV發(fā)揮作用，藥效學研究其抗抑郁效果可與ODV媲美，但給藥劑量大為降低，臨床應(yīng)用前景廣闊，未來可期。

成果應(yīng)用案例介紹

聯(lián)系方式

電話/微信: 13822630888

相關(guān)成果

免責聲明 / 網(wǎng)站地圖 / 平臺簡介 / 友情鏈接

郵箱：zeccea@qq.com QQ群：318441538 客服電話：0758-2721389 秘書處電話/微信：13822630888

基本文件流程錯誤 SQL 調(diào)試

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[ BEHAVIOR ] Run Closure @app_init [ RunTime:0.000013s ]
[ CACHE ] INIT File
[ BEHAVIOR ] Run \addons\briefurl\Briefurl @app_init [ RunTime:0.001287s ]
[ BEHAVIOR ] Run \addons\fastflow\Fastflow @app_init [ RunTime:0.000025s ]
[ BEHAVIOR ] Run \addons\notice\Notice @app_init [ RunTime:0.000265s ]
[ BEHAVIOR ] Run \addons\qrcode\Qrcode @app_init [ RunTime:0.000181s ]
[ BEHAVIOR ] Run \addons\treaty\Treaty @app_init [ RunTime:0.000028s ]
[ BEHAVIOR ] Run \addons\upyun\Upyun @app_init [ RunTime:0.000015s ]
[ BEHAVIOR ] Run Closure @app_init [ RunTime:0.000031s ]
[ BEHAVIOR ] Run app\common\behavior\Common @app_init [ RunTime:0.000236s ]
[ LANG ] /www/wwwroot/open.juabc.com/thinkphp/lang/zh-cn.php
[ BEHAVIOR ] Run app\common\behavior\Common @app_dispatch [ RunTime:0.000012s ]
[ ROUTE ] array ( 'type' => 'module', 'module' => array ( 0 => 'index', 1 => 'results', 2 => 'views', ), )
[ HEADER ] array ( 'host' => 'www.cqximen.com', 'user-agent' => 'Mozilla/5.0 (Windows NT 10.0; WOW64; Trident/7.0; rv:11.0) like Gecko', 'referer' => 'http://www.baidu.com', 'cookie' => 't=92d7540e476b153862b4ea2356ede7b3; r=8148', 'accept-language' => 'zh-CN,zh', 'accept-encoding' => 'gzip, deflate', 'accept' => 'text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8', 'content-type' => 'application/x-www-form-urlencoded; Charset=UTF-8', 'connection' => 'Keep-Alive', 'content-length' => '', )
[ PARAM ] array ( 'ids' => '4405', )
[ LANG ] /www/wwwroot/open.juabc.com/public/../application/index/lang/zh-cn.php
[ BEHAVIOR ] Run app\common\behavior\Common @module_init [ RunTime:0.000685s ]
[ BEHAVIOR ] Run \addons\upyun\Upyun @module_init [ RunTime:0.000112s ]
[ BEHAVIOR ] Run \addons\wxfollowlogin\Wxfollowlogin @module_init [ RunTime:0.000017s ]
[ BEHAVIOR ] Run \addons\upyun\Upyun @upload_config_init [ RunTime:0.000378s ]
[ BEHAVIOR ] Run \addons\editpage\Editpage @config_init [ RunTime:0.000031s ]
[ BEHAVIOR ] Run \addons\notice\Notice @config_init [ RunTime:0.000021s ]
[ DB ] INIT mysql
[ BEHAVIOR ] Run \addons\csmtable\Csmtable @action_begin [ RunTime:0.000035s ]
[ RUN ] app\index\controller\Results->views[ /www/wwwroot/open.juabc.com/application/index/controller/Results.php ]
[ VIEW ] /www/wwwroot/open.juabc.com/public/../application/index/view/results/views.html [ array ( 0 => 'user', 1 => 'site', 2 => 'config', 3 => 'data', 4 => 'active', 5 => 'login', 6 => 'catelist', 7 => 'views', ) ]
[ BEHAVIOR ] Run \addons\wxfollowlogin\Wxfollowlogin @view_filter [ RunTime:0.000051s ]

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